Evidence that the insulin receptor-associated protein kinase acts as a phosphatidylinositol kinase.
نویسندگان
چکیده
Insulin receptor preparations from human placenta at various states of purity were shown to catalyze insulin-stimulated phosphate incorporation from [gamma-32P]ATP into endogenous (membrane) and exogenous phosphatidylinositol. Our data suggest that the insulin receptor associated protein (tyrosine) kinase can act as a phosphatidylinositol kinase, and that this mechanism may be of physiological importance in signal transduction of insulin.
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عنوان ژورنال:
- FEBS letters
دوره 175 1 شماره
صفحات -
تاریخ انتشار 1984